| EPSRC Reference: |
GR/S78896/01 |
| Title: |
A New Fibre-optic Sensor for Measuring Splanchnic Blood Perfusion |
| Principal Investigator: |
Kyriacou, Professor P |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Engineering and Mathematical Sci |
| Organisation: |
City, University of London |
| Scheme: |
First Grant Scheme Pre-FEC |
| Starts: |
01 October 2004 |
Ends: |
30 September 2007 |
Value (£): |
118,040
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| EPSRC Research Topic Classifications: |
| Med.Instrument.Device& Equip. |
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Summary on Grant Application Form |
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Splanchnic organs such as the intestine, liver and kidney are particularly vulnerable to hypoperfusion. Splanchnic ischaemia may occur intraoperatively or in critical care patients in clinical situations such as low flow states of cardiogenic or hypovolaemic origin, in severe inflammation such as Systemic Inflammatory Response Syndrome or severe infection. As a result, it may ultimately lead to cellular hypoxia and necrosis, and may well contribute to the development of multiple organ failure and increased mortality. Multiple organ dysfunction syndrome remains a common cause of death and morbidity following major surgery despite advances in intensive care management. The clinical evaluation of splanchnic, especially intestinal, ischaemia and viability is often subjective and unreliable. To assess splanchnic viability the visual impression by the surgeon must be supported by a technical measurement of oxygenation or blood flow. To date there is no widely accepted and readily available intraoperative or postoperative technique to quantify intestinal blood flow or oxygenation and therefore assess the viability. Current techniques used to measure tissue oxygenation and blood flow in the splanchnic area have various drawbacks and limitations. Specifically: (a) Most of them are used only as research tools; (b) they are relatively expensive, intermittent, operator dependent and time consuming; (c) most of them are indicative of only blood flow and not tissue oxygenation; (d) none of them could be left in the abdomen for prolonged postoperative monitoring; (e) none of the current techniques has been used to investigate the correlation between blood oxygen saturation and blood flow in an ischaenic splanchnic organ(s). The proposed project will produce and clinically evaluate a non-invasive or semi-invasive, novel pulse oximeter probe which will be used for the continuous estimation of splanchnic blood oxygen saturation, based on fibre optic technology. This novel sensor may be left in situ on the abdominal viscera intraoperatively, postoperatively and in intensive care for the continuous monitoring of tissue perfusion in patients at high risk of developing visceral ischaemia. Further, we propose to accompany the above development by a computational and theoretical investigation of the blood flow through a stenotic mesenteric artery of variable stenotic degree aiming at establishing the relation between degree of the stenosis in this artery and oxygen saturation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.city.ac.uk |