| EPSRC Reference: |
GR/S79268/01 |
| Title: |
Glycochips-strategies for high-throughput analysis of the glycome |
| Principal Investigator: |
Flitsch, Professor S |
| Other Investigators: |
| Crocker, Professor PR |
Haslam, Professor SM |
Turnbull, Professor J |
| Dell, Professor A |
Field, Dr R |
Gouverneur, Professor V |
| Feizi, Professor T |
Russell, Professor D |
Davis, Professor B |
| Donohoe, Professor T |
Fairbanks, Professor AJ |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Edinburgh |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 2004 |
Ends: |
30 July 2005 |
Value (£): |
3,570,609
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Carbohydrate Chemistry |
| Chemical Biology |
Combinatorial Chemistry |
| Genomics |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Carbohydrate-protein interactions are critical in many important biological events, in particular on cell surfaces. The aim of the present project is to develop carbohydrate arrays (glycochips) as innovative tools to map out the carbohydrate and protein partners in these biologically important interactions of the glycome (the complete set of carbohydrate structures produced by a particular cell or tissue). The project brings together a diverse set of novel technologies in the generation of carbohydrate microarrays (from natural sources, by chemical and enzymatic synthesis), in high throughput expression of carbohydrate binding proteins and in the analyses of binding proteins through mass spectrometry. An understanding of the cell's glycomeprotein interactions complements data from studies of the proteome (protein-protein interactions) and represents an essential facet post-genome technology development that will underpin exploitation through development of novel glycotherapeutics in diverse applications such as malignant disease, viral and bacterial infections, inflammation, innate and acquired immunity, neurodegeneration, wound healing and tissue engineering.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ed.ac.uk |