| EPSRC Reference: |
GR/S81629/01 |
| Title: |
The Catalytic Generation and Trapping of Chiral Enolates |
| Principal Investigator: |
Willis, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bath |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2004 |
Ends: |
30 September 2007 |
Value (£): |
95,333
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Enolate-electrophile bond constructions are amongst the most efficient in organic synthesis. The aim of this research is to extend this type of bond-forming event by developing methodology that will allow chiral enolates to be generated under catalytic conditions using soft-enolisation techniques. We will investigate the structural requirements needed for efficient enolate generation and the variety of electrophiles that can be trapped.Specific areas for investigation are the synthesis of alpha, beta-diamino acids, Darzens and aza-Darzens reactions and direct enantioselective conjugate additions. The key feature of all the enolates we plan to employ is that they have the ability to allow an intramolecular trap following the key bond construction. This feature leads to the synthesis of a variety of highly functionalised heterocyclic systems that are extyremely useful building blocks for synthesis.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bath.ac.uk |