Details of Grant 

EPSRC Reference:	GR/S91161/01
Title:	Developing the Benzannulation Strategy to Aromatic Boronic Esters
Principal Investigator:	Harrity, Professor JPA
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Sheffield
Scheme:	Standard Research (Pre-FEC)
Starts:	04 October 2004	Ends:	03 October 2007	Value (£):	71,924
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Summary on Grant Application Form
This proposed work aims to establish a conceptually new approach to a range of aryl boronic esters by the employment of alkynylboronates in a series of benzannulation reactions. Importantly, this strategy allows direct incorporation of the synthetically useful boronate moiety into highly substituted and functionalised aromatic synthetic intermediates. Initial studies will focus on exploring the scope of alkynylboronates in the Dotz annulation reaction both in the context of the reaction mechanism and the synthetic intermediates which can be accessed. Additionally, and in a wide context, we. hope to demonstrate that alkynylboronates will participate in [4+2] cycloaddition reactions towards similar aromatic boronic esters in an effort to develop a more economical process which avoids the use of stoichiometric transition metal organometallics.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk Summary Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:
Further Information:
Organisation Website:	http://www.shef.ac.uk