Details of Grant 

EPSRC Reference:	GR/S93585/01
Title:	New mathematical models for cell motility
Principal Investigator:	Oliver, Dr JM
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Sch of Mathematical Sciences
Organisation:	University of Nottingham
Scheme:	Postdoc Res Fellowship PreFEC
Starts:	01 November 2004	Ends:	31 October 2007	Value (£):	104,703
EPSRC Research Topic Classifications:	Cells Continuum Mechanics
EPSRC Industrial Sector Classifications:	Environment Healthcare Pharmaceuticals and Biotechnology
Related Grants:
Panel History:	Panel Date Panel Name Outcome 03 Feb 2004 PDF in Mathematics 2003/2004 - Sift Deferred
Summary on Grant Application Form
The commercial development of the next generation of medical implant and fixation devices will benefit significantly from a more quantitative understanding of how a single animal cell moves over a biomaterial surface. This project aims to develop and analyse pertinent new mathematical models that account for modern knowledge of the underlying molecular biology, chemistry and physics of the main mechanical components responsible for self-propelled cell motion. I intend to do this through my ongoing collaboration with the biomaterials and cell motility experts at the University of Nottingham. To make the models computationally tractable, I intend to use systematic modern mathematical simplification techniques to exploit the disparate length and time scales that characterise a typical cell crawling cycle. The resulting reduced models will be studied using a range of analytic and numerical techniques, with the objective of testing their predictions for the spatio-temporal evolution of the main mechanical components with those that can be imaged through microscopy experiments (e.g. the morphology of the plasma membrane); relevant images and data will be obtained in part through the experiments that I will coordinate in the coming year as a PDRA in the Biomaterials Groups on a highly relevant Postdoctoral Mobility project.
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Organisation Website:	http://www.nottingham.ac.uk