| EPSRC Reference: |
GR/S95633/01 |
| Title: |
Tracking particle deposition in the turbulent human airway |
| Principal Investigator: |
Luo, Professor X |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Mathematics & Statistics |
| Organisation: |
University of Glasgow |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 March 2005 |
Ends: |
29 February 2008 |
Value (£): |
149,957
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| EPSRC Research Topic Classifications: |
| Medical science & disease |
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Summary on Grant Application Form |
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The understanding and quantative assessment of local air flow fields and micron-particle deposition distribution in tracheo-broncial airways are highly important for estimating the effects of certain inhaled pollutants, and the efficiency of the delivery of aerosol drugs, such as those used to treat airway inflammation in asthma. Although advanced imaging as well as computational modelling techniques have been employed to obtain deposition patterns in the upper airways, almost none of these modellings have considered the important influences of the turbulent flow on particle depositions, due to the difficulties of modelling turbulence as well as particle tracking in the turbulent flow. This project is to evaluate influences of turbulent flow on particle depositions in a simple airway model. This will be achieved by employing the two most advanced numerical techniques: LES and KS. The former can successfully simulate the turbulent flow on the larger scales, which is what is needed by KS for the particle tracking. The combination of these two CFD techniques provided a novel approach to the challenging problem at hand, and promises fruitful results. The outcome of the work is likely to have a big impact on drug industry and clinical sector.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |