Details of Grant 

EPSRC Reference:	GR/T03727/01
Title:	Ultra-high speed Non-contact Force Microscopy
Principal Investigator:	Miles, Professor MJ
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Physics
Organisation:	University of Bristol
Scheme:	Senior Fellowship (Pre-FEC)
Starts:	01 October 2004	Ends:	30 September 2009	Value (£):	353,916
EPSRC Research Topic Classifications:	Chemical Biology Materials Characterisation
EPSRC Industrial Sector Classifications:	Pharmaceuticals and Biotechnology
Related Grants:
Panel History:	Panel Date Panel Name Outcome 26 May 2004 Fellowships Central Allocation Panel Deferred 19 Mar 2004 Materials Fellowships 2004 Sift Panel Deferred
Summary on Grant Application Form
The recent development in Bristol of ultra-high-speed AFM and SNOM has leap-frogged developments worldwide to build a high-speed AFM. The resonant scanning technique combined with state-of-art data capture electronics provide a platform for developments over an extremely broad front which will impact on many disciplines from molecular biology to materials.This proposal aims to provide the time for the applicant to take this progress with the ultra-high-speed scanning platform and develop an ultra-high-speed transverse dynamic force microscope (TDFM) operating in non-contact mode in liquid environment. The invention of such a microscope would allow biomolecular processes to be followed at the millisecond timescale and in physiologically relevant environment.There are several possible routes in which this might be achieved based on our new techniques. There are two staring points(i) high-amplitude resonance of the TDFM vertical probe with real-time Fourier filtering to remove the fundamental harmonic and enhance the high-frequency components that correspond to higher spatial frequencies;(ii) resonance of specimen stage under vertically mounted probe and collection of displacement of probe as a result of the varying strength of coupling with the moving specimen through the confined water layer reflecting the surface topography.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk Summary Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:
Further Information:
Organisation Website:	http://www.bris.ac.uk