| EPSRC Reference: |
GR/T17007/01 |
| Title: |
MEARS (Molecularly Engineered Amperometric Recognition Scaffolds) in electrode composite biosensor materials |
| Principal Investigator: |
Hall, Professor EAH |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Institute of Biotechnology |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 November 2004 |
Ends: |
30 June 2008 |
Value (£): |
309,202
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| EPSRC Research Topic Classifications: |
| Chemical Biology |
Chemical Synthetic Methodology |
| Materials Processing |
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Summary on Grant Application Form |
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There are lessons and analogies from basic biosensor construction that can aid new strategies if we approach from a molecular design, materials and engineering viewpoint. If the substrate-binding site from the enzyme could be linked with the redox centre without the rest of the protein, then an enzyme mimic results, which may be suitable for use and development as an analytical reagent. The aim of this programme is to design materials for Molecularly Engineered Amperometic Recognition Scaffolds (MEARS) as constructs for biosensors. The system is based on a functionalised active electrode material with molecular level definition. MEARS is a novel and flexible approach to biosensing. The core of this MEARS technology is a molecularly'wired' actuator that has undergone biomimetic derivatisation to include an analyte recognition site. Synzyme-electrode-composite materials will be researched, with peptidomimetics grafted to create a recognition site on the synzyme, whose occupancy attenuates the redox properties of the synzyme. The RGD peptidomimetic will be targeted for integrin detection as an indicator of cancer and will be tested to detect alphavbeta3 integrin.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |