| EPSRC Reference: |
GR/T22346/01 |
| Title: |
Innovative polysaccharide microcapsule templates in hard & soft tissue engineering |
| Principal Investigator: |
Oreffo, Professor R |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Development Origin of Health and Disease |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2005 |
Ends: |
31 March 2008 |
Value (£): |
204,156
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Tissue Engineering |
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Summary on Grant Application Form |
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The development of simple biodegradable materials with broad applicability and tissue/ cell specificity has to date proved elusive. Thus the development of simple platform technologies to generate materials/scaffolds of wide ranging potential is an urgent medical need. We propose to use self-assembled mineral-polysaccharide scaffolds of specified composition and physico-chemical properties in combination with selectively isolated and expanded human mesenchymal stem cells to create template constructs ideally suited to the engineering of a broad range of tissues. The microcapsules will be functionalized by carbodiimide chemistry to generate peptide /alginate/chitosan constructs with recognition peptides, as well as augmented with additional anionic polymers such as glycosaminoglycans by complexation with chitosan prior to microcapsule self-assembly.To achieve this, we describe a multidisciplinary research programme between Southampton and Bristol that harnesses expertise in: i) mesenchymal stem cell technology, lineage manipulation and tissue engineering (Southampton) with, ii) expertise in biomimetic materials chemistry and biomineral inspired fabrication/self assembly of scaffolds.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.soton.ac.uk |