| EPSRC Reference: |
GR/T24319/01 |
| Title: |
Imide Desymmetrisation for Alkaloid Synthesis |
| Principal Investigator: |
Simpkins, Professor NS |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 November 2004 |
Ends: |
30 June 2007 |
Value (£): |
140,957
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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Summary on Grant Application Form |
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The proposed research is aimed at developing the desymmetrisation approach as a powerful strategy for converting readily available imides of various types into useful complex chiral products, especially alkaloids, which have important diverse biological activities. By enabling novel and very concise access to nitrogen containing systems it may be possible to make available complex chiral alkaloids, related to natural products, by extraordinarily short and stereocontrolled routes, thus making them attractive for pharmaceutical applications. Non-nitrogenous targets, including very important anti-cancer compounds of the lignan lactone families, will also be made available.In order to achieve these objectives we need to invent new and efficient chemical reactions and apply them in concise desymmetrisation approaches. This will involve exploration of organometallic additions, chiral base chemistry, ring-expansion reactions and enolate protecting group strategies.The new chemistry will be tested and applied in diverse areas so as to establish its scope and limitations, and it will be used to access attractive synthetic targets by extremely concise routes.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |