| EPSRC Reference: |
GR/T26351/01 |
| Title: |
Ferrocene-based enantioselective sensors for chiral carboxylates |
| Principal Investigator: |
Tucker, Professor JH |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
University of Birmingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2005 |
Ends: |
30 June 2009 |
Value (£): |
244,161
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Asymmetric Chemistry |
| Chemical Synthetic Methodology |
Co-ordination Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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The ultimate goal of the project is to establish whether the enantiomeric composition of a chiral compound can be conveniently and rapidly determined (i.e. 'read-out') using electrochemistry. This will be done by preparing a series of enantiopure chiral receptors that contain both ferrocene and urea moieties. In each receptor, the ferrocene moiety will be used as the redox-active reporter group and the urea function(s) will be used to bind the chiral target through hydrogen-bonding interactions. Those receptors that contain alkanethiol moieties will be immobilised onto gold electrodes or gold clusters to form self-assembled monolayers. Binding studies will be carried out using a variety of techniques, in particular proton NMR spectroscopy. The ferrocene groups on each receptor will allow the binding of the chiral targets at the urea function(s) to be monitored by electrochemical techniques (e.g. cyclic voltammetry), through changes in the ferrocene-centred redox couple. Significant and reproducible differences between the redox properties of a particular receptor upon binding opposite enantiomers of a chiral carboxylate anion will signify an effective electrochemical 'read-out' of enantioselectivity. The work will be of a multi-disciplinary nature, involving synthesis, binding studies and electrochemistry.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bham.ac.uk |