| EPSRC Reference: |
EP/C520645/1 |
| Title: |
Microfluidics with Electrode Integration for Blood Cells Dynamic Studies |
| Principal Investigator: |
Vadgama, Professor P |
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| Department: |
Biomedical Materials |
| Organisation: |
Queen Mary University of London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
17 May 2005 |
Ends: |
16 May 2006 |
Value (£): |
8,056
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Summary on Grant Application Form |
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Microfluidics involves the study of flow-through devices having channels generally with at least one sub - millimetre dimension. A class of microfluidic devices are used for blood samples, for flow cytometry, cell manipulation or cell separation.The proposed project aims to study the differential manipulation / separation of blood cells according size, shape and electric polarizability in microfluidic flow. Separation forces will be induced by applying an electric ! magnetic field to pressure driven flows of diluted suspensions of blood cells.Novel devices with microchannels containing coated walls as electrodes and arrays of insulated vertical / horizontal wires as magnetic inductors as well as hydraulic obstacles will be used. The electrodes will be vapour deposed metals, coated with organic (aminoacids) ceramic (titania) layers. Electric voltage application (DC or AC) will result in electrodes through a planar condenser effect, via sol-gel titania as dielectric. The wall coatings will also act as adhesion traps.During the actuation of movement cell suspensions, interaction with the electric and magnetic fields will determine a different response of erythrocytes vs various types of leucocytes. This will produce either a different cell adhesion location at the channels walls, or a different relative position at the exit stream, which will be further studied and modelled.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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