| EPSRC Reference: |
EP/C546105/1 |
| Title: |
Optical Proteomic Technology for In-Situ Analysis of Protein Interaction Networks |
| Principal Investigator: |
Irving, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Biomolecular Sciences |
| Organisation: |
Kings College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
24 October 2005 |
Ends: |
23 February 2010 |
Value (£): |
1,000,300
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Genomics |
| Lasers & Optics |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proteomics research programme will aim at the development of radical new technologies to address the major outstanding challenges in our understanding of the functional interactions of proteins. Non-invasive analysis of intact/live biological cells is made possible by optical techniques . This will enable the study of protein function within a truebiological context, which is not possible with existing approaches. A high-speed high-throughput implementation of the new technologies will allow the extended network of protein-protein interactions that regulate cell function and determine specific physiological responses to be unravelled. Optical technology development will focus on robust high-speed imaging and methods for the detection of protein interactions occurring specifically on the cell surface, which offers many potential drug targets. These new proteomic technologies will benefit a number of important biomedical issues, including stem cells, cancer, allergy and asthma. This research programme builds on the availability of the human genome to bridge the gap between advanced optical cell imaging, cell biology and clinical medicine.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Organisation Website: |
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