| EPSRC Reference: |
EP/D03454X/1 |
| Title: |
Ultrasonic manipulation and transport of DNA molecules in evanescent light fields |
| Principal Investigator: |
Hill, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Faculty of Engineering & the Environment |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
13 August 2006 |
Ends: |
12 January 2010 |
Value (£): |
379,811
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| EPSRC Research Topic Classifications: |
| Chemical Biology |
Instrumentation Eng. & Dev. |
| Microsystems |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Ultrasonic Standing Waves (USWs) can be used to manipulate particles within a fluid. Used within chambers of a half wavelength depth or less, the ultrasonic radiation forces can move the particles either to a central plane within the chamber or to a wall of the chamber. This project is a multidisciplinary investigation into the use of USWs in microfluidic biosensing applications. It involves the School of Engineering Sciences (SES), the Optoelectronics Research Centre (ORC) and the Microelectronics Research Centre in the Department of Electronics and Computer Science (ECS) at the University of Southampton. The work aims to integrate optical sensing and USW excitation using techniques and materials compatible with emerging microfluidic technology. It will also use the optical/USW techniques to study and quantify the behaviour of the USW chamber, particularly with regard to the ability of quarter wavelength chambers to move particles to the chamber wall. The project will apply these techniques to the detection of a number of DNA sequences in a mixture. It will also investigate the feasibility of using acoustic radiation forces to interrogate single DNA sequences with a high resolution.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.soton.ac.uk |