Details of Grant 

EPSRC Reference:	EP/E024211/1
Title:	A tissue-engineered orthopaedic implant to treat bone defect
Principal Investigator:	Hua, Professor J
Other Investigators:	Blunn, Professor G Coathup, Dr MJ Goodship, Professor A
Researcher Co-Investigators:
Project Partners:
Department:	Institute of Orthopaedics
Organisation:	UCL
Scheme:	Standard Research
Starts:	23 April 2007	Ends:	22 October 2010	Value (£):	371,715
EPSRC Research Topic Classifications:	Tissue Engineering
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:
Summary on Grant Application Form
Revision total hip replacements due to aseptic loosening, caused by wear particle induced osteolysis, are surgically costing and affect patients' life quality. The reduction of bone stock available for subsequent implant fixation is responsible for poorer results. Currently there is no consistent method which can effectively repare bone defects and restore bone stock.The aims of this project is to develop a tissue-engineered orthopaedic implant which can treat bone defects in revision total hip replacements. The innovatin of the study is to combine techniques in tissue engineering science, biomaterila science and implant design.A biomaterial called trabecular metal will be used for scaffold, which is made of porous tantalum with three dimensional porous structure. Biomimetic layer of calcium and phosphate will be deposited through the structure
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