Details of Grant 

EPSRC Reference:	EP/I036516/1
Title:	Ambient Pressure Mass Spectrometry at the Sub Micron Scale
Principal Investigator:	Webb, Professor RP
Other Investigators:	Ward, Professor NI Kirkby, Professor KJ
Researcher Co-Investigators:
Project Partners:	Kings College London Natural History Museum NERC Grouped Sheffield Hallam University UCL University of Cambridge University of Lincoln University of Oxford
Department:	ATI Electronics
Organisation:	University of Surrey
Scheme:	Standard Research
Starts:	05 December 2011	Ends:	31 March 2016	Value (£):	1,278,391
EPSRC Research Topic Classifications:	Analytical Science
EPSRC Industrial Sector Classifications:
Related Grants:
Panel History:	Panel Date Panel Name Outcome 22 Mar 2011 Novel Technologies for Cross-disciplinary Research Interview Panel Announced 01 Mar 2011 Novel Technologies for Cross-disciplinary Research Sift Panel Meeting Announced
Summary on Grant Application Form
This proposal aims to develop a new ambient pressure mass spectrometry imaging system. It will use a beam of ions accelerated to MeV potential energy - velocities of the order of 5% the speed of light or less. The beam will be focussed using a set of quadrapole magnetic lenses to less than a micron in size and will be passed out of the vacuum system through a 100nm thick silicon nitride window into air where it will be able to travel between 0.5-1.0cm before stopping. A sample placed in front of this beam of ions will be sputtered (eroded) by the interaction of the ions with the electrons in the system (electronic energy loss). Previous experiments in vacuum have demonstrated that if the sample is a molecular material it is possible to extract large (~45kDa) molecular species from the surface and that these can be detected in a Time of Flight mass spectrometer to determine their molecular mass. Fragments that are removed at the same time give indications about the bonding arrangements of the molecules sputtered and can be used to determine the probable molecular arrangement. The beam itself can be raster scanned using an electrostatic field so that a molecular map of the surface of the material can be determined at the micron scale. The ions as they enter the surface of the material are moving fast enough that they will also cause electrons in the outer shells of the atoms that they pass to become exited and in relaxing back will give out a characteristic X-ray. These X-rays can also be collected and analysed using a technique known as Partical Induced X-ray Emmision (PIXE) to give trace element maps as well. This will be the worlds first scanning mass spectrometer capable of imaging at the sub micron scale in air. Applications for this equipment range from forensics to biomedicine taking in geology and the environment as well as helping to understand the origins and manufacture of art and archeological remains. These applications will be encouraged over the period of the project.
Key Findings
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Potential use in non-academic contexts
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Further Information:
Organisation Website:	http://www.surrey.ac.uk