| EPSRC Reference: |
EP/L505328/1 |
| Title: |
Guide Cardiac Resynchronisation Therapy - Guide CRT |
| Principal Investigator: |
Rhode, Professor KS |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Imaging & Biomedical Engineering |
| Organisation: |
Kings College London |
| Scheme: |
Technology Programme |
| Starts: |
17 March 2014 |
Ends: |
16 September 2017 |
Value (£): |
454,212
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| EPSRC Research Topic Classifications: |
| Med.Instrument.Device& Equip. |
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| EPSRC Industrial Sector Classifications: |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
Cardiac Resynchronisation Therapy (CRT) has been shown to be a safe and effective treatment option in patients with
advanced drug-refractory Heart Failure (HF), systolic dysfunction and ventricular dyssynchrony. However, up to one-third of
patients implanted with a CRT device show no improvement in symptoms and up to half of patients show no improvement
in cardiac function. These non-responders are a strong burden to healthcare systems by causing considerable
unnecessary costs, e.g. for devices, implantations, recurring follow-up visits as well as hospitalisations for acute HF
decompensation The aim of this project is to develop a single platform which integrates all stages of the CRT pipeline,
referred to as the "Guide CRT", to improve response rate. The main components of this include MR clinical imaging
protocols dedicated to HF patients, tailored image processing tools (segmentation of the heart morphology, myocardial scar
and coronary sinus, as well as analysis of left ventricle (LV) wall motion), fused visualisation for improved patient selection
and planning of LV lead placement, and the image-based guidance technologies to support CRT device implantation.
Guide CRT will be evaluated on a cohort of 50 patients. Through the proposed joint efforts between leaders in their
respective industrial, academic and clinical fields, we aim to demonstrate that integrating comprehensive multimodal
imaging data and tools can help to provide answers to the great challenges of CRT, namely identification of patients who
are likely to respond and guiding LV lead placement to maximise this reponse.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
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