| EPSRC Reference: |
GR/A01039/01 |
| Title: |
AF: DEVELOPMENT OF OPTIMISED TISSUE ENGINEERED CARTILAGE USING MECHAMICAL PRECONDITIONING BIOREACTOR |
| Principal Investigator: |
Knight, Professor MM |
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| Department: |
Biomedical Materials |
| Organisation: |
Queen Mary University of London |
| Scheme: |
Advanced Fellowship (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 November 2006 |
Value (£): |
217,632
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Summary on Grant Application Form |
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Articular cartilage is the specialised tissue within synovial joints, which protects the bone from high stresses during normal activity. When cartilage becomes damaged due to trauma or disease it has a very limited repair potential such that initially small lesions often progress to total cartilage degradation and the onset of the painful and debilitating condition of osteoarthritis. This research programme aims to develop a system to provide a fully functional restoration of damaged articular cartilage using tissue engineering techniques. The proposed approach is to isolate the patients own cells and then to seed these within a biodegradable scaffold. The design and characterisation of a suitable scaffold will form a major part of the proposed programme. Prior to implantation, the cell seeded scaffold will be maintained within a bioreactor designed to mechanically stimulate the cells synthesis of cartilaginous matrix which will ultimately replace the scaffold material and provide the repair tissue. This use of mechanical stimulation is based on the knowledge that mechanical forces stimulate cellular synthesis of cartilage matrix in vivo through a process termed 'mechanotransduction'. The proposed research programme aims to investigate mechanotransduction within a cell seeded scaffold in order to design a bioreactor in which mechanical conditioning will be used to produce an optimised tissue engineered cartilage.
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Key Findings |
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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