| EPSRC Reference: |
GR/J58176/01 |
| Title: |
NANOSTRUCTURES FOR THE OPTICAL TRAP TECHNIQUE |
| Principal Investigator: |
Simmons, Professor R |
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| Department: |
Biophysics Cell and Molecular Biology |
| Organisation: |
Kings College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 1994 |
Ends: |
30 September 1995 |
Value (£): |
18,503
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Summary on Grant Application Form |
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The aim of the project is to produce microfabricated surfaces for experiments on the properties of biological macromolecules (especially actin and myosin), using the optical trap technique. In these experiments, a filamentous macromolecule (actin) is attached to a 1mm diameter polystyrene bead, which is then trapped at the focus of a laser beam in a light microscope. The macromolecule is then made to interact with binding proteins (myosin) coating a coverslip, and the force and displacement produced is measured from the movement of the bead. Raised nanoscale features on the coverslip are required to restrict the number of interacting molecules, to permit single interactions to be observed. Optically dense marks on the coverslip are needed for micropositioning.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
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| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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