| EPSRC Reference: |
GR/L57906/01 |
| Title: |
NEW CHIRAL ORGANIC CATALYSTS FOR NON-METAL-MEDIATED GROUP TRANSFER FROM FUNCTIONAL SILANES |
| Principal Investigator: |
Lawrence, Professor N |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
UMIST |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 1997 |
Ends: |
30 September 2000 |
Value (£): |
40,581
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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We propose the synthesis of a series of new cheap, non-toxic chiral organic fluorides for the metal-free catalysis of the general transfer of nucleophiles from polymeric silanes to carbonyl compounds. These will be based on the common achiral fluoride sources tetrabutyylammonium fluoride, TASF [tris (dimethylamino) sulfur (trimethylsilyl) difluoride] and tetrabutylammonium difluorotriphenylstannate and the related silicate. These will be used to catalyse the asymmetric addition and allyl nucleophiles to prochiral aldehydes and ketones from novel polysiloxanes. Part of the study will involve the synthesis of some of these polysiloxanes (a) from an appropriate dichloro or dimethoxysilane and (b) from polymethylhydrosiloxane. We will study the mechanism of this novel type of catalysis which we refer to as a zipper-type reaction.The project will provide cheap, environmentally benign and convenient methods for the fluoride-catalysed asymmetric nucleophilic addition of hydride and carbon nucleophiles to carbonyl compounds. Unlike existing methods our protocol will obviate the need for rigorously anhydrous conditions and will avoid the hazards associated with organometallic reagents.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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