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Details of Grant 

EPSRC Reference: GR/L83646/01
Title: ORGANIC LIGANDS FOR TRANSITION METAL COMPLEXES RELATED TO COFACTORS OF MOLYBDENUM/TUNGSTEN ENZYMES
Principal Investigator: Joule, Professor J
Other Investigators:
Collison, Dr D Garner, Professor C D
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: Victoria University of Manchester, The
Scheme: Standard Research (Pre-FEC)
Starts: 01 January 1998 Ends: 30 April 2001 Value (£): 146,957
EPSRC Research Topic Classifications:
Biological & Medicinal Chem.
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
The total synthesis of the transition metal pteridine (TMPT) ligand of the molybdenum and tungsten enzymes would be completed, then metal complexes synthesised for spectroscopic and biological comparisons with the natural systems.The synthesis of structurally modified analogues of the TMPT, including quinoxalines and pteridines, would be followed by formation of transition metal complexes from these, and then their electrochemical, spectroscopic and biological evaluation aimed at gaining information about the following aspects of the mechanism of action of these enzymes:a What geometry at the metal is essential for catalytic oxygen transfer activity?b What is the role of TMPT(s) in the catalytic process?c What is the form of TMPT at the active site during catalytic turnover?d Does the structure of the organic ligand remain the same throughout the catalytic process?e Is there interplay between the oxidation state of the metal and that of the TMPT?
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