| EPSRC Reference: |
GR/M50843/01 |
| Title: |
THE STEREOSELECTIVE BIRCH REDUCTION OF FURANS AND PYRROLES |
| Principal Investigator: |
Donohoe, Professor T |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
Victoria University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
08 November 1999 |
Ends: |
07 November 2001 |
Value (£): |
107,354
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This proposal is designed to investigate the Birch reduction of electron-deficient furans and pyrroles. Our early studies have shown that the basic reduction reaction works very well. This chemistry is at an exciting stage and we ask for support to really extend the methodology and apply it to natural products synthesis.We have developed the stereoselective Birch reduction of furans: this is a powerful reaction that we wish to apply to the synthesis of several interesting pyrrolidizine alkaloids: our routes are novel and particularly concise. This methodology could also be extended greatly by the reduction of hetero-atom substituted furoic-acid derivatives. We propose a synthesis of these heterocycles and also an application of the reduction to another useful class of natural product.We also have several interesting leads derived from the Birch reduction of pyrrole (this is a reaction that we developed ourselves). We want to explore these new reactions and apply the chemistry that we discover to the synthesis of biologically-active natural products. For example, we have discovered the reductive aldol reaction and also want to explore an interesting new doule reductive alkylation reaction of both pyrroles and furans.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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