| EPSRC Reference: |
GR/M63690/01 |
| Title: |
TOTAL SYNTHESIS OF THE NATURALLY-OCCURING ANTICANCER AGENT HALICHOMYCIN |
| Principal Investigator: |
Hale, Professor K |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2000 |
Ends: |
30 June 2003 |
Value (£): |
200,592
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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In this research programme we will attempt to synthesise the novel anticancer agent halichomycin. Halichomycin is a structurally unprecedented macrolide of marine origin first encountered and characterised by Numata and colleagues in Japan in the early to mid 1990's/ Halichomycin has powerful anticancer properties, and as such, could prove to be of significant clinical potential for the treatment of human cancers. A synthesis of halichomycin will give medicinal chemists an appropriate and useful synthetic pathway that can be used to make analogues for anticancer drug screening.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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