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Details of Grant 

EPSRC Reference: GR/M78496/01
Title: NOVEL OSTEO-INTEGRATIVE ORTHOPAEDIC BIOMATERIALS
Principal Investigator: Revell, Professor PA
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Destiny Pharma Ltd
Department: Pathology
Organisation: UCL
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 2001 Ends: 31 March 2003 Value (£): 150,943
EPSRC Research Topic Classifications:
Biomaterials Tissue Engineering
EPSRC Industrial Sector Classifications:
Healthcare Transport Systems and Vehicles
Related Grants:
Panel History:  
Summary on Grant Application Form
A major unresolved clinical problem in the management of orthopaedic conditions is the ability to implant orthopaedic prostheses, which achieve permanent fixation to surrounding bone. Presently, metal devices, whether cemented or non-cemented, show only poor osteointegration with a finite lifetime before loosening; porous ceramic coatings provide improvements but do not offer complete resolution. There therefore remains a clinical need to develop novel approaches to ensuring effective osteointegration of orthopaedic implants. The positioning of a biomaterial with a physical ultra-structure capable of forming a scaffold for osteogenic cell attachment between the (bone:implant) interface may be advantageous in promoting osteointegration. Previous research has shown that cells can be successfully grown in vitro in calcium-crosslinked alginate beads. This proposal therefore aims to investigate the use of calcium-cross linked carboxylated polysaccharides, such as calcium alginate and calcium pectinate in combination with other biodegradable and biocompatible polysaccharides such as chitosan for the production of a molecular scaffold for osteogenic cell attachment between the {bone:implant} interface to enhance osteo-integration for primary use within existing uncemented orthopaedic prostheses.
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