| EPSRC Reference: |
GR/M89904/01 |
| Title: |
SELECTIVE EPIMERISATION OF ORGANIC COMPOUNDS USING POLARITY-REVERSAL CATALYSIS |
| Principal Investigator: |
Roberts, Professor B |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 December 1999 |
Ends: |
30 November 2001 |
Value (£): |
124,535
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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In pilot experiments, we have shown that some simple organic molecules which contain two or more chiral centres can be selectively epimerised at chiral tertiary CH centres under conditions of polarity-reversal catalysis (PRC). We propose to build on this proof-of-principle and carry out a detailed study of the application of PRC to bring about selective radical-chain epimeristion at CH centres in a variety of types of molecule. When the CH-centre also carries an electron-donating group, a protic catalyst will be appropriate, while when an electron-withdrawing group is present, an hydridic catalyst will be used. The factors that govern catalyst efficiency will be identified and used to design effective protic and hydridic epimerisation catalysts. Once the basic ground rules have been established, the methodology will be applied to the epimerisation of more complex molecules, such that readily-available diastereoisomers can be selectively converted into rare or unknown diastereoisomers in a simple way. The methods developed will also be applied to the interconversion of non-stereoisomers, with an aim of providing new, simple and enviornmentally-clean routes to desirable organic compounds.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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