| EPSRC Reference: |
GR/N20546/01 |
| Title: |
DEVELOPMENT OF TOFSIMS INSTRUMENTATION AND METHODOLOGY FOR CHEMICAL OF CELLULAR SYSTEMS |
| Principal Investigator: |
Vickerman, Professor JC |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 2000 |
Ends: |
30 April 2003 |
Value (£): |
328,262
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Biochemical studies provide the key to understanding and exploiting microorganisms and also, crucially, the control of infectious deseases. There is a critical requirement to develop tools to allow cell biologists to study complex chemistry within individual cells. The propsed research is the culmination of four years EPSRC funded instrument development from which a high sensitivity chemical microscope (ToFSIMS) has evolved with the analytical capability to probe complex chemistry with high magnification and high sensitivity. In collaboration with microbiologists, a three year project is now proposed which plans to advance the instrumentation specifically for cellular analysis and validate ToFSIMS for the first time in microbial cell chemistry research. Funds are requested to provide the necessary hardware (freeze-fracture facilities and essential upgrade to our post-ionisation laser system), for consumables, to support a microbiologist post-doctoral research associate and postgraduate research student and cover technician costs.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.man.ac.uk |