| EPSRC Reference: |
GR/N20959/01 |
| Title: |
SYNTHETIC STUDIES ON THE NATURALLY-OCCURRING ANTI-HIV AGENT HAPLOSAMATE B |
| Principal Investigator: |
Hale, Professor K |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 February 2001 |
Ends: |
31 January 2003 |
Value (£): |
121,110
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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(-)-Haplosamate B is a naturally-occurring HIV-1 integrase inhibitor isolated from a marine sponge. It is currently in very short supply and further quantities of this material will need to become available if it is ever to be clinically explored as a future treatment of AIDS. In this proposal, we have outlined a novel strategy for obtaining (-)-Haplosamate B by chemical synthesis. We are proposing ab initio assembly of this complex steroid via an elaborate polyene cascade cyclisation sequence based on consecutive free radical cyclisations. We intend to use our chemistry to access analogues of this important molecule, in addition to making it available to clinicians.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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