| EPSRC Reference: |
GR/N23677/01 |
| Title: |
IMI - DESIGN OF TECHNIQUES & FACILITIES TO MANUFACTURE EFFECTIVE INEXPENSIVE ANTIVENOMS |
| Principal Investigator: |
Price, Professor C |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Sch of Medicine & Dentistry |
| Organisation: |
Queen Mary University of London |
| Scheme: |
LINK |
| Starts: |
01 July 2000 |
Ends: |
30 June 2003 |
Value (£): |
381,494
|
| EPSRC Research Topic Classifications: |
| Design of Process systems |
Separation Processes |
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The programme comprises: (1) The choice of species for immunisation and the source of antibodies. Currently, most antivenom procedures use horses but we have substantial evidence that favours sheep. We also intend to compare antibody production in other mammals and avian systems.(2) Initial extraction and purification. These studies are designed to separate intact immunoglobulins of the IgG class from the many other proteins, especially albumin, found in whole blood, plasma, serum or the yolk of eggs. Such step(s) will probably be the first stage in manufacturing a therapeutic product. (3) Final product purification and formulation. This comprises protease digestion of the antibodies and final purification of the relevant immunoglobulin fragment. Final formulation will provide a stable liquid dosage form. (4) Engineering the manufacturing system will aim to devise a simple and robust process that can be reliably implemented in developing countries that currently lack antivenom production capabilities. Finally,(5), housing the manufacturing process will involve engineering design companies to design a portable clean room facility for the entire manufacture of antivenoms.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
|