| EPSRC Reference: |
GR/N30743/01 |
| Title: |
(ROPA) THE ATOM EFFICIENT GENERATION,STRUCTURE & REACT IVITY OF UNKNOWN METAL ENOLATES FOR ORGANIC SYNTHESIS |
| Principal Investigator: |
Motherwell, Professor WB |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
UCL |
| Scheme: |
ROPA |
| Starts: |
06 September 2000 |
Ends: |
05 February 2003 |
Value (£): |
104,564
|
| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
|
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
A range of hitherto unknown metal enolates will be prepared in pure form using transition metal catalysts to mediate isomerisation of allylic metal akoxide precursors. The structure and reactivity of the products will be examined with particular attention given to reactions such as the regio-and stereospecific generation of tetrasubstituted enolates which are problematic using the atom inefficient deprotonation of carbonyl compounds by amide bases. The use of chiral ligands around the metals, in conjunction with prochiral allylic alcohols should provide useful chiral units for synthesis.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
|