| EPSRC Reference: |
GR/N38787/02 |
| Title: |
(ROPA) A NEW ROUTE TO C-4 SUBSTITUTED INDOLE ALKALOIDS |
| Principal Investigator: |
Bailey, Professor PD |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
UMIST |
| Scheme: |
ROPA |
| Starts: |
01 October 2001 |
Ends: |
31 December 2002 |
Value (£): |
66,117
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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Summary on Grant Application Form |
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In 1999, we discovered a novel rearrangement of a Swern oxidation intermediate, which generated tryptophan derivatives substituted by the MeSCH2 group at the C-4 position, in low yield (ca 30%).In the proposed research, we aim to:a) Optimise the reaction, and study its scope/limitationsb) Explore how the C-4 MeSCH2 group can be derivatised.c) Complete the total synthesis of one important indole alkaloid -Clavicipitic Acid, Agroclavine or Indolactam V-the choice depending on the results from phases a) nad b).
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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