| EPSRC Reference: |
GR/R11506/01 |
| Title: |
A Cell Seeded Degradable Co-Culture System For Ligament Regeneration & Attachment To Bone |
| Principal Investigator: |
Salih, Dr V |
| Other Investigators: |
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| Department: |
Eastman Dental Institute |
| Organisation: |
UCL |
| Scheme: |
Fast Stream |
| Starts: |
01 January 2001 |
Ends: |
31 December 2003 |
Value (£): |
47,508
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Tissue Engineering |
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Summary on Grant Application Form |
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One of the major problems currently encountered in hard and soft tissue surgery, is the attachment of either synthetic of natural grafts for the repair of tissue injured by disease or trauma. Of particular interest in this proposal, is the attachment of a ligament to bone and this has major implications both in dentistry for the attachment of the periodontal ligament to the tooth and the underlying bone and also for the repair of the cruciate ligament in the knee. Recent work in the biomaterials department, in conjunction with the applicant, has shown that soluble phosphate glass fibres provide an ideal substrate on which to culture bones and ligament cells. This project is aimed at using initially animal but eventually, human derived tissue to produce a co-culture on the glass fibres. Initial experiments, will examine ligament cells and bone cells separately, on the fibres and the cellular activity studied by both conventional biological methods, but also, advanced molecular methods, such as studies of gene activity, using already established protocols. From this work, co-cultures will be developed in such a way that ligament cells will be at one end and bone cells at the other. Using digital microscopy facilities already available, coupled with the new in-situ incubator, time lapse studies will be carried out to follow the progression of the tissue development and of particular interest, will be the interaction of the two cell types as they migrate along the fibres.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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