| EPSRC Reference: |
GR/R20465/01 |
| Title: |
A New Approach To the Synthesis of Breynolide |
| Principal Investigator: |
Grainger, Dr RS |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Kings College London |
| Scheme: |
Fast Stream |
| Starts: |
01 July 2001 |
Ends: |
30 June 2004 |
Value (£): |
63,833
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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This project seeks to develop new methods of preparing the key structural features of the sulfur-containing antibiotic breynolide. Application of the rich organic chemistry associated with sulfur is the key to the synthesis of the left-hand portion of the molecule. A new means of stereoselective synthesis is proposed based on a symmetry breaking cycloaddition reaction of a sulfenic acid with an alkene. A study on the nature of this reaction using different alkenes will increase our fundamental knowledge of the system. The sulfoxide group formed as a consequence of this cyclisation will De used to further aid in the synthesis of more complicated derivatives. A model for the right hand portion of breynolide will be synthesised in a small number of synthetic steps using a photochemical ring closing reaction, which dramatically increases molecular complexity. A combination of these IWO new strategies will be applied to the synthesis of simple model compounds related to breynolide, which may also display significant biological activity.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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