| EPSRC Reference: |
GR/R28935/01 |
| Title: |
Mathematical Modelling Myocardial Conduction and Its Relationship To Sudden Arrhythmic Death |
| Principal Investigator: |
Dawes, Professor WN |
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| Department: |
Engineering |
| Organisation: |
University of Cambridge |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
31 January 2005 |
Value (£): |
320,332
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| EPSRC Research Topic Classifications: |
| Medical science & disease |
Non-linear Systems Mathematics |
| Theoretical biology |
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Summary on Grant Application Form |
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Clinical studies have shown that in patients with hypertrophic or dilated cardiomyopathy, the LOTS and primary VF, increased electrogram fractionation in response to premature extrastimuli is associated with a high risk of sudden arrhythmic death. It is believed that electrogram fractionation is a sign of discontinuous conduction and hence the presence of a potential substrate for VF. Similar results to those seen in LOTS patients have been obtained in the isolated, Langendorff perfused, ferret heart with either dofetilide or anthopleurin-A in the perfusate, suggesting that fractionation in the LOTS is related to delayed repolarisation. A preliminary mathematical model of 200x200 blocks loom square has been used to investigate fractionation in the LOTS. A 70% reduction in Ikr with small variation in refractory period causes causes fractionation closely mimicking that seen in humans and isolated hearts. We propose to make a mathematical model of the isolated rabbit heart based on measured fibre angles and AP kinetics that can incorporate fibrous tissue or repolarisation current change and will be solved using optimal spatial gridding techniques. The electrograms computed from the model will be compared to those measured in an isolated heart using a new 500-point mapping procedure.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cam.ac.uk |