| EPSRC Reference: |
GR/R41767/01 |
| Title: |
Catalysts, asymmetric synthesis of cyanohydrins. |
| Principal Investigator: |
North, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Kings College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
92,996
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
| Combinatorial Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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23 May 2001
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Chemistry Single Panel May 2001
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Deferred
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Summary on Grant Application Form |
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Over the last seven years we have been developing new catalysts for the asymmetric conversion of carbonyl compounds and trimethylsilyl cyanide into cyanohydrins. Recently, we discovered a completely novel variation of this chemistry, namely that it is possible to use a mixture of potassium cyanide and an anhydride in place of trimethylsilyl cyanide. This discovery opens the way for the first industrially exploitable asymmetric synthesis of cyanohydrins and has been patented by King's College. In this proposal we will study the mechanism of this reaction and use the resulting information to optimize both the reaction conditions and the structure of the catalyst. A number of reaction parameters will be studied both for the mechanistic information that varying them provides, and to optimize the parameter. These include the structure of the catalyst, especially the nature of the transition metals, the structure of the anhydride, and the nature of any additives. One key question which we will seek to see to address is hoe the solid potassium cyanide is able to enter into the reaction solution, and in particular whether a metal salen complex is acting as a phase transfer catalyst in this reaction. We will then demonstrate the utility of our methodology by applying it to the solid phase asymmetric synthesis of cyanohydrins and derived compounds.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
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