| EPSRC Reference: |
GR/R43594/01 |
| Title: |
ROPA: Monitoring Connective Tissue Organisation in Tissue Engineering & Repair by Elastic-Scattering Spectroscopy |
| Principal Investigator: |
Brown, Professor RA |
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| Department: |
Surgery |
| Organisation: |
UCL |
| Scheme: |
ROPA |
| Starts: |
03 December 2001 |
Ends: |
02 June 2004 |
Value (£): |
143,476
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Summary on Grant Application Form |
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Elastic Scatter-spectroscopy using fine optic fibres is a novel, inexpensive and minimally invasive technique with potential formonitoring tissue density and microarchitecture critical to tissue engineering and repair. Pilot studies have successfully monitored changes in collagen in a common tissue engineering model: fibroblast contracting collagen lattices. With the analysis of polarised light scatter, the influences of collagen density alignment will be evaluated in vitro, in whole tissues and in skin and tendon repair in vivo to identify characteristic signals associated with new tissue formation and integration. This has exciting potential for clinical monitoring tissue repair and tissue engineered constructs.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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