| EPSRC Reference: |
GR/R61604/01 |
| Title: |
Catalytic Borylation via C-H and C-F Bond Activation |
| Principal Investigator: |
Perutz, Professor R |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of York |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
27 May 2002 |
Ends: |
26 September 2005 |
Value (£): |
156,965
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Arylboronate esters and boronic acids have numerous direct uses (e. . in glucose sensors, neutron capture therapy for treatment of malignant melanoma and brain tumours) and are key intermediates in the Suzuki-Miyaura -&-catalysed cross-coupling reaction for the formation of biaryls, a widely employed methodology for pharmaceuticals synthesis and the manufacture of liquid crystals. Transition metal catalysts for the synthesis of arylboronates directly from arenas, fluoroarenes and their heteroarene analogues (the simplest starting materials, yet the most difficult to functionalise) via C-H and C-F activation will be developed as a cost effective general route to these commercially important compounds. Stoichiometric reactivity of novel metal-boryl and metal-aryl compounds along with reaction kinetics and mechanistic studies of individual steps related to the catalytic processes will be studied to obtain a better understanding of the fundamental aspects of this chemistry, and these results will be used to guide catalyst development and optimisation. Modem methods of rapid parallel catalyst screening will also be employed to improve the efficiency by which suitable candidates for more detailed analysis can be identified. The combination of parallel screening with mechanistic studies is an extremely powerful approach to catalyst development which we have found to be highly successful in the past...
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.york.ac.uk |