| EPSRC Reference: |
GR/R65954/01 |
| Title: |
Investigating the dissolution of amorphous and semi-amorphous particles in simulated lung fluid. |
| Principal Investigator: |
Royall, Dr P |
| Other Investigators: |
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| Department: |
Pharmacy |
| Organisation: |
Kings College London |
| Scheme: |
Fast Stream |
| Starts: |
07 January 2002 |
Ends: |
06 April 2005 |
Value (£): |
63,057
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Drug Formulation & Delivery |
| Medical science & disease |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Healthcare |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This study seeks to explore the interactions between relevant model drugs and excipients in their amorphous or partially amorphous forms with simulated lung fluids. The optimal lung fluid will be chosen by the deconvolution of solution calorimetry heat flow data into its thermodynamic and kinetic components. These components will be used to rank order the different lung fluid models. The development of this analytical approach will provide a means to characterise the stability and mechanism for the dissolution of peptide and protein dry powder formulations designed for pulmonary delivery. A training set will be used that will contain representatives of typical amorphous forming materials including model proteins. These will be rendered amorphous and semiamorphous, using a range of industrial processes. Solution calorimetry will be used to characterise the mechanism and kinetics for the dissolution of the amorphous materials in the training set. The generated heat flow, as a function of time, will be fitted to new or modified models of dissolution behaviour using iterative procedures and regression analysis. This kinetic modelling will provide the mechanism, order and rate constant for the dissolution process, in addition to the amount of amorphous material present. Modulated temperature differential scanning calorimetry will be used to measure the glass transition temperatures of the traning set and combining this with the dissolution analysis will allow the relationship between Tg and the dissolution rate to be studied. Such a novel investigation will determine how formation conditions modulate the increase in bioavailability for the amorphous form of a drug.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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