| EPSRC Reference: |
GR/S05151/01 |
| Title: |
High Relaxivity Gadolinium Complexes |
| Principal Investigator: |
Parker, Professor D |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
Durham, University of |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2003 |
Ends: |
31 March 2006 |
Value (£): |
215,349
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
Drug Formulation & Delivery |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The synthesis and physicochemical characterisation of a series of well-defined gadolinium complexes, and conjugates possessing one or two innersphere waters that undergo fast exchange under ambient conditions. The elaboration of these systems with 3 or 4 biocompatible, hydrophilic substituents which enhance relaxivity but do not impair water exchange kinetics and may allow reversible binding to serum albumin in order to optimise the overall relaxivity. Using this knowledge, a folate-targeted conjugate will be evaluated based on a high relaxivity Gd complex devised herein, regioselectively coupled to the X-C02H group of folic acid.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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