| EPSRC Reference: |
GR/S08053/01 |
| Title: |
Non invasive spatially resolved measurement of blood oxygenation using photoacoustic spectroscopy |
| Principal Investigator: |
Beard, Professor PC |
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| Department: |
Medical Physics and Biomedical Eng |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2003 |
Ends: |
30 September 2006 |
Value (£): |
251,842
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| EPSRC Research Topic Classifications: |
| Instrumentation Eng. & Dev. |
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Summary on Grant Application Form |
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he aim of this project is to develop a promising new means of non invasively measuring blood oxygenation using time-resolved photoacoustic spectroscopy. In this approach, the spectroscopic dependence of blood oxygenation is encoded on to laser generated ultrasound waves enabling spatially resolved measurements. The technique is broadly applicable to basic research and clinical investigations into normal and pathophysioloc, processes characterised by changes in tissue oxygenation status. One such application that will be investigated is the study of oxygenation heterogeneity in cancerous tumours which is important for research into tumour physiology and clinically predicting therapeutic outcome. The proj will involve experimental and theoretical work to develop and validate novel methodologies for quantitatively extracting measurements of blood oxygenation from spectroscopic photoacoustic signals. A non-invasive fibre optic photoacoustic oxygenation sensor that provides a 1 D depth prof oxygen saturation will be developed for in vivo use and a pilot animal study of tumour oxygenation undertaken. This project builds upon our previc work in biomedical photoacoustic spectroscopy and NIR spectroscopic studies of tissue oxygenation and complements our current work in photoacoustic imaging (funded through the Pls EPSRC Adv. Fellowship and a recently awarded 3 year EPSRC project grant). Indeed, the broade objective is to combine the latter with the spectroscopic methodologies developed under this proposal to obtain 3D images of tissue oxygenatio
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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