| EPSRC Reference: |
GR/S27733/01 |
| Title: |
Towards a Biogenetically-Modelled Tpotal Synthesis of Halichomycin |
| Principal Investigator: |
Hale, Professor K |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 2003 |
Ends: |
30 June 2006 |
Value (£): |
213,068
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Biological & Medicinal Chem. |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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In this programme we will attempt to complete the first asymmetric total synthesis of the powerful antitumour agent halichomycin by a biogenetically -mo( cyclisation strategy that will close all three of its medium-sized ether/hemimacrolactam rings by a novel, one-pot, reaction cascade applied on the branch precursor, pre-halichomycin (1). It is postulated that the highly stereodefined structure of 1 and its arrangement of functionality will permit the respective reactive termini to react in the desired way. Molecular models of 1 indicate that cyclisation should lead to the correct ring-system 6, if successful.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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