| EPSRC Reference: |
GR/S31051/01 |
| Title: |
Development and Validation of Mathematical Models for in Vitro Tissue Growth |
| Principal Investigator: |
King, Professor J |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Sch of Mathematical Sciences |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
09 February 2004 |
Ends: |
08 August 2006 |
Value (£): |
124,532
|
| EPSRC Research Topic Classifications: |
| Continuum Mechanics |
Non-linear Systems Mathematics |
|
| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
|
| Related Grants: |
|
| Panel History: |
| Panel Date | Panel Name | Outcome |
|
28 Feb 2003
|
Mathematics Prioritisation Panel (Science) Feb 03
|
Deferred
|
|
|
Summary on Grant Application Form |
|
Mathematical models for tissue growth in a bioreactor will be constructed. The models will primarily involve parabolic (reaction-convection-diffusion) models of mass transport and elliptic equations describing growth-driven tissue deformation, with a moving boundary delineating the edge of a growing cell colony. Asymptotic and computational methods will be used to produce physical insight into the parameter dependencies, together with robust numerical packages. The models will be validated against experimental data obtained by, interalia, the Tissue Engineering Group in the School of Pharmaceutical Sciences at Nottingham.Various sub-problems will need to be addressed in the course of model development (cell seeding; mass transport; tissue growth; blocking and degradation of the scaffold; and fluid flow) and the various couplings between these phenomena will require accounting for in generating a widely applicable 'bioreactor function', which will provide a predictive tool for describing how bioreactor performance depends on scaffold and cell properties.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.nottingham.ac.uk |