Details of Grant 

EPSRC Reference:	GR/S54685/01
Title:	Quantitative medical opticeal tomography using a priori anatomical information
Principal Investigator:	Gibson, Professor AP
Other Investigators:
Researcher Co-Investigators:
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Department:	Medical Physics and Biomedical Eng
Organisation:	UCL
Scheme:	Advanced Fellowship (Pre-FEC)
Starts:	01 October 2003	Ends:	28 February 2009	Value (£):	209,306
EPSRC Research Topic Classifications:	Image & Vision Computing Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:	Panel Date Panel Name Outcome 28 May 2003 Engineering Advanced Fellowships Interview Panel Deferred 02 May 2003 Engineering Fellowships Sift Panel 2003 Deferred
Summary on Grant Application Form
In optical tomography of the neonatal head and breast, near infrared light illuminates the body and transmitted light measured at multiple points on the surface. Optical tomography can generate images of blood volume and oxygenation quantitatively due to the different absorption spectra of oxy- and deoxygenated haemoglobin. The quantitative accurate however, depends on the spatial resolution due to the partial volume effect.I will use a priori information from magnetic resonance imaging (MRI) to constrain the optical image reconstruction. will improve the spatial resolution and provide the first quantitatively accurate 3D in vivo optical tomography image: obtain simultaneous MR and optical images by modifying our existing hardware and then use anatomical information MRI to condition the optical modelling and image reconstruction. I will also develop a system for using generic a pri information so that optical tomography can be performed at the bedside without requiring a patient-specific MR ima providing a safe, portable system for obtaining quantitative images of blood volume and oxygenation. This will be invaluable in neonatal intensive care, where babies are generally too ill to be moved, and it will allow suspicious breast lesions to be identified without requiring a biopsy.
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