| EPSRC Reference: |
GR/S56306/01 |
| Title: |
Segmentation of the Motor Pathways in Man: A Tool for Investigating Neurological Disability |
| Principal Investigator: |
Clark, Professor CA |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Clinical Neuroscience |
| Organisation: |
St George's University of London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
05 April 2004 |
Ends: |
04 April 2005 |
Value (£): |
47,725
|
| EPSRC Research Topic Classifications: |
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The pathways of the white matter in the brain are very difficult to identify on conventional magnetic resonance images (MRI). A new MRI technique known as diffusion tensor imaging (DTI) can be used to quantitatively map white matter structure and orientation. Computer algorithms can then be applied to the orientation data to trace out the white matter pathways of the brain in vivo.The cortico-spinal tracts (CST) carry important information connecting the motor cortex to the spinal cord, controlling the motor function of the body. In many neurological diseases or conditions, such as multiple sclerosis or stroke, damage to the CST results in disablity. A method capable of segmenting the CST and isolating its structural status would have great value in monitoring the natural history of damage to the CST and will help to elucidate the mechanisms of neurological disability.In this project we propose to explore and develop new fibre tracking methodologies for the reliable, accurate and automatic segmentation of the CST. We will optimise the tracking method and input parameters and then test the segmentation procedure in normal healthy brains. The CST segmentation will then be used to evaluate CST damage in a small cohort of stroke patients exhibiting motor dysfunction implicating the CST.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
|