| EPSRC Reference: |
GR/S71637/01 |
| Title: |
Reactivity and Function of Diaqua Lanthanide Complexes |
| Principal Investigator: |
Parker, Professor D |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemistry |
| Organisation: |
Durham, University of |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2004 |
Ends: |
30 September 2007 |
Value (£): |
189,792
|
| EPSRC Research Topic Classifications: |
| Chemical Biology |
Gas & Solution Phase Reactions |
|
| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The elaboration of the reaction chemistry of diaqua lanthanide complexes in aqueous media, in which inter or intramolecular binding of selected anions is examined as a function of anion concentration/pH. Control over binding affinity is achieved by tailoring complex structure and by permutation of the Ln ion itself. The function of these complexes include an optical pH probe suitable for minituarisation using pH or pZn switched sulfonamide ligation, a sensitive MRI method for measuring pZn in the nanomolar range and an exploration of the reactivity of chelated alpha-ketoacids (pyruvate, oxaloacetate, 2-oxyglutarate), or keto-amides with a view to enantioselective catalysis of reduction or reductive amination.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
|