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Details of Grant 

EPSRC Reference: EP/I010173/1
Title: Beating Hearts at High Resolution: Adaptive High Resolution Selective Plane Illumination Microscopy
Principal Investigator: Love, Professor G
Other Investigators:
Girkin, Professor J Quinlan, Professor R
Researcher Co-Investigators:
Project Partners:
Department: Physics
Organisation: Durham, University of
Scheme: Standard Research
Starts: 01 March 2011 Ends: 31 March 2015 Value (£): 506,510
EPSRC Research Topic Classifications:
Development (Biosciences) Lasers & Optics
Optical Phenomena
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
EP/I010122/1
Panel History:
Panel DatePanel NameOutcome
08 Jul 2010 Physical Sciences - Physics Announced
Summary on Grant Application Form
In this project we will film life as it develops in the heart by exploiting developments in optical microscopy, high speed imaging, and adaptive optics. The hearts will be in live, developing zebrafish and mouse embryos. This is extremely challenging as the living heart is large (on a microscopic scale), is embedded in the body of the animal (meaning it must be imaged at depth) and is beating, and therefore moving, at a rate of around 300 beats per minute. As well as providing a challenge to demonstrate the advanced methods we will develop the study of cardiac development is important both for investigating the development of the healthy heart and for determining the causes of heart problems.
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