Details of Grant

EPSRC Reference:

GR/R45659/01

Title:

BIO-NANOTECHNOLOGY IRC

Principal Investigator:

Other Investigators:

Watts, Professor A	Cooper, Professor J	Pethica, Professor J
Trentham, Dr D	Molloy, Dr J	Turberfield, Professor AJ
Armitage, Professor J	Sansom, Professor M

Researcher Co-Investigators:

Professor A Asenov	Professor Dame FM Ashcroft	Professor RM Berry
Professor R Codgell	Dr J Corrie	Professor DRS Cumming
Professor PJ Dobson	Dr D Doyle	Dr J Eccleston
Dr M Ferenczi	Professor MLH Green	Professor H Hill
Dr J Hoggett	Professor N Isaacs	Professor L Johnson
Professor N Johnson	Professor AG Lee	Professor H Morgan
Professor RJ Nicholas	Professor D Sherratt	Professor G Smith
Professor RE Sockett	Professor E Southern	Professor JC Sparrow
Dr RK Thomas	Dr C Veigel	Professor JMR Weaver
Professor C Wilkinson	Professor J Yeomans

Project Partners:

Department:

Oxford Physics

Organisation:

University of Oxford

Scheme:

Standard Research (Pre-FEC)

Starts:

01 April 2002

Ends:

31 March 2009

Value (£):

9,829,772

EPSRC Research Topic Classifications:

Biological & Medicinal Chem.	Biomaterials
Cells	Chemical Biology
Microsystems

EPSRC Industrial Sector Classifications:

Electronics	Healthcare
Pharmaceuticals and Biotechnology

Related Grants:

Panel History:

Summary on Grant Application Form

The IRC aims to investigate biomolecular systems, from the level of single molecules up to complex molecular machines, to establish the principles of their function and apply this knowledge to produce artificial electronic and optical devices:Molecular motors are proteins in which enzymatic activity such as energy conversion and self-assembly are integrated to produce highly efficient linear or rotary motion on a nanometre length scale. The combination of structural biology, molecular genetics and biophysics will allow the mechanisms to be characterised and potential applications to be identified.Membrane proteins can be viewed as one of evolution's main attempts at nano-engineering: they include ion channels, hormone receptors and photoreceptors. High resolution (spatial and temporal) studies of ion channels and related membrane proteins will be made via novel time-resolvedoptical spectroscopy and single molecule techniques.'Molecular genetic analysis needs efficient ways of comparing sequences: to search for mutations it is necessary to scan entire gene sequences. Combined nano-fabrication and genetics methods will be used to produce patterned surfaces, and more sensitive methods of detecting interactions will be developed in order to push toward the single molecule limit.Single-molecule electronics and photonics will be used to develop novel devices, networks and sensors.Single molecule and scanning probe experimental techniques including AFM, STM, optical and dielectric traps, FTIR, and SNOM will underpin the entire IRC programme. Theoretical approaches with common themes will be developed and applied - including Monte Carlo methods, atomic force models, and techniques derived from semiconductor device simulations.

Key Findings

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Potential use in non-academic contexts

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Impacts

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Summary
Date Materialised

Sectors submitted by the Researcher

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Project URL:

Further Information:

Organisation Website:

http://www.ox.ac.uk